Cell shape changes induced by cationic anesthetics.
نویسندگان
چکیده
منابع مشابه
Cell shape changes induced by cationic anesthetics
The effects of local anesthetics on cultivated macrophages were studied in living preparations and recorded in still pictures and time-lapse cine-micrographs. Exposure to 12mM lidocaine or 1.5 mM tetracaine resulted in rounding in 10-15 min. Rounding was characterized by cell contraction, marked increase in retraction fibrils, withdrawal of cell processes, and, in late stages, pulsation-like ac...
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The primary mode of action of local anesthetics is through sodium channel and axonal conduction blockade. Local anesthetics have also extensive effects on pre-synaptic calcium channels that must function to stimulate the release of neurotransmitters. Thus, interference with calcium channel conductance may enhance spinal anesthesia with local anesthetics. The present study was designed to invest...
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Mitochondria are highly dynamic organelles, the location, size and distribution of which are controlled by a family of proteins that modulate mitochondrial fusion and fission. Recent evidence indicates that mitochondrial morphology is crucial for cell physiology, as changes in mitochondrial shape have been linked to neurodegeneration, calcium signalling, lifespan and cell death. Because immune ...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1976
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.143.2.290